The effect of Kardeh (Biarum Bovei) Hydro-alcoholic extract on pain threshold in STZ induced diabetic rats

Authors

  • Hossein Sazgar Department of Biology, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
  • Maryam Rafieirad Department of Biology, Izeh Branch, Islamic Azad University, Izeh, Iran
  • Masomeh Seifi Zangeneh Department of Biology, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
Abstract:

Background & Aim: Diabetes mellitus in long-term through various means such as augmented oxidative stress is associated with disturbances such as pain and cognition in humans and laboratory animals. According to the evidence of anti-diabetic extract of Biarum Bovei (BB), Effect of oral administration of this extract was evaluated on blood glucose level and pain threshold in diabetic rats. Experimental: Animals were divided into; Control (intact), diabetic (STZ 70 mg /kg) and diabetic group that received Biarum Bovei Extract (BBE) (50, 100, 200, 400, 800 mg/kg) for two weeks by gavage. Blood glucose was measured from tail blood, then performed tail filick test to measure pain threshold. The results were analyzed statistically through SPSS, One way ANOVA and Tukey's test. Diabetes led to a decrease in blood glucose (p < 0.001) and pain threshold (p <0.001) prescribed doses (100, 200 mg/kg) BBE resulted a decrease in blood glucose (p  Results & Discussion: The findings of this study showed that Hydro-alcoholic extract of kadeh (BB) possibly with high-antioxidant property is able to reduce blood glucose and diabetes complications such as pain in animals. Recommended applications/industries: Considering the low side effects of herbal medicines, especially antioxidants including Kardeh can be used to reduce the complications of diabetes with drug therapy.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

the effect of kardeh (biarum bovei) hydro-alcoholic extract on pain threshold in stz induced diabetic rats

background &amp; aim: diabetes mellitus in long-term through various means such as augmented oxidative stress is associated with disturbances such as pain and cognition in humans and laboratory animals. according to the evidence of anti-diabetic extract of biarum bovei (bb), effect of oral administration of this extract was evaluated on blood glucose level and pain threshold in diabetic rats. e...

full text

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

Effects of Hydro-Alcoholic Leaf Extract of Kardeh (Biarum Bovei Blume) on the Blood Glucose and Lipid Peroxidation in Cerebral Tissues and Lipid Profile in Streptozotocin Induced Diabetic Rats

Objective: Oxidative stress is the result of an imbalance between free radical production and antioxidant defenses of the body. The use of antioxidants can have preventive effects in diabetes. The present study aims to show the effects of Biarum Bovei extracts on lipid profile, lipid peroxidation in streptozocin induced diabetic male rats. Materials and Methods: Animals were randomly assigne...

full text

The effect of date aqua extract and melatonin on diabetic neuropathy in STZ-induced diabetic rats

Introduction: Diabetes mellitus is often associated with chronic neuropathy, a condition which is due to the disturbance in the function of peripheral nervous system. Studying the effects of antioxidants in relieving neuropathy is of a great clinical importance. The aim of this study was to compare the effect of aqua extract of date and Melatonin in preventing neuropathic hyperalgesia in Strept...

full text

Effect of alcoholic extract of Iranian red onion on diabetic neuropathic pain in streptozotocin-diabetic rats

Introduction: Neuropathic pain is one of the common complications of diabetes mellitus which is caused by impairment in nerve conductivity. The role of flavonoid and polyphenol compounds in treatment of neuropathic pain has been revealed, and extract of onion contains significant amounts of these compounds. The aim of this study was to investigate the effect of alcoholic extract of onion on ...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 6  issue 3 Special issue (in Persian or Farsi)

pages  137- 142

publication date 2015-11-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023